The Body Will Slow Its Metabolism to Compensate for Caloric Restriction

Why Caloric Restriction Does NOT Work

Caloric Restriction Is Not Effective

Introduction

 Suminthran P. Long-term persistence 
of hormonal adaptations to weight loss. N 
EnglJ Med. 2011 Oct 27;

intro

Caloric Restriction Is Not Effective

Evolution has built in the ability for our bodies to compensate and adapt to constantly changing environments.  It only makes sense that the evolution creates mechanisms to compensate for situations where food is scarce as well as when food is abundant.  

There are 2 major adaptations to caloric reduction

  • The first is a dramatic reduction in total energy expenditure
  • The second is that the hormonal signals that stimulate hunger increase.
In situations where food is scarce, the body compensates immediately by decreasing your metabolism.  The metaboli machinery of your body will slow down in order to preserve energy.  They after all, do not know when and where the next meal might come from.  Studies have shown that not only does your metabolism react to the absence of food by decreasing your metabolism.  Studies have also shown that the decrease is prolonged for days and weeks in response to decreased calories.  This is presumably a compensatory mechanism as you never know when the next meal will come.

 

Weight loss significantly increases ghrelin levels even after more than one year

  • Means that subjects felt hungrier and continued to feel hungry

Satiety hormones peptide yy, amylin, and cck all decreased after more than a year!

  • This means that hunger is increased and satiety is decreased!

The desire to eat rises

  • These hormonal changes occur almost immediately and persists

Subjects in the Minnesota Starvation experiment “dreamed of food” and obsessed about food

Functional MRI’s even show that emotion and cognition areas in the brain light up to food stimuli

Evolutionary purpose- regain lost weight!

Breaking Insulin Resistance is the Answer to Losing Weight

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